The temperature was lowered down to 25 C. At that temperature hydrogel started absorbing water and swelling and then it was again raised up to 37 C.
By doing in this way, researchers saw that around 80% of the attached cells dropped by. The fellow researchers of Giant repeated the temperature change procedure every 60 minute, and continued to do it for four hours. After the experiment the researchers said that a sensor coated fully with the gel keeps it free from fibrous growth around it and it demonstrated well.
In a second test membrane was made porous. It was observed that analytes like glucose move through to the sensor without making its ability ineffective to monitor the conditions such as diabetes and providing read-out.
To prevent the sensors from immune defence and to attain the desired changes and results the sensors are coated with membrane and placed under the surface of the skin. These sensors are then regulated through an external mean; which is a device integrated with a heating and cooling element to change the temperature.
Megan Frost is a researcher working at Michigan Technological University in Houghton, US. She is fascinated by these findings. She says,
“The idea of shrinking and swelling is novel to the best of my knowledge”
Earlier the researchers made much research work on creating such substances which could prevent the fibroblasts from getting attention. These substances don’t behave to cause the immune response.
Frosts says that by using a membrane which possesses both chemical properties and physical properties – shrinking and swelling – could successfully keep the implanted sensors clean than any other material. She says that
We would be waiting to see how it results in the real body, because there is a very little correlation in the lab experiments and actual happening. Despite of seeing the astonishing and positive results by experimenting on cell cultures in test tubes, she is suspicious about its behavior in real body. She thinks that it is more likely that we see the shrinking and growing membrane creating new problems when used in the body.
“Physical movement sometimes increases the inflammatory response to implanted devices”
Danny O’Hare is working at Imperial College London, UK since many years. He feels that the movements caused by the physical properties could create complications. He thinks that it would probably affect the performance of the sensor.
“It’s hard to see how the optical or spectroscopic properties of the tissue-sensor interface won’t be adversely affected by the swelling/shrinking membrane,”